In 2007A0192, the overall goals "are to elucidate precise mechanisms by which nocitine alters synapse organization in the brain. ... The proposed studies will increase our comprehension of the underlying molecular mechanisms of nicotine addiction. "

The stress paradigms include Elevated Plus Maze, Light-Dark Test, Startle Response Test, Forced Swim Test, and Restarint Test (placed in a tube for 30 min.)

Mice are used in this study.

In 2007A0193 , they are looking at some pesticides used in agriculture. "The pilot study is designed to examine the effects of neonicotinoids and maternal stress on changes in neuronal nicotinic receptor levels during fetal development.

Rats in used in this study

In both studies timed pregnant females are used and "At birth, newborn pups will be grouped by sex, decapitated with sharp scissors, and the brain removed for receptor binding studies.

As a side issue neonicotinoids are being looked at in other scientific circles as possibly one of the reasons for the decline in bee colonies.