2005A0040 - Effects of Vf Compounds on Focal Ischemia Reperfusion Injury of The Brain
Arturo J. Cardounel & Greg Christoforidis
Pain Code = 7D

One baboon will be used which is being "procured from the University of Illinois."

"This is a feasibility study aimed at generating preliminary data for a grant resubmission in which the PI needs to demonstrate the ability to employ the model proposed."

What will happen to the baboon?

"New anti-oxidant compounds will be tested using a primate model of stroke. The stroke will be caused by passing a small catheter into the brain circulation. This catheter is fitted with a balloon on the end and when the balloon is inflated blood cannot flow to the surrounding areas of the brain. The result of this is similar to what happens in humans when they have a stroke."

The baboon is under anesthesia and the procedures to create a stroke in the animal performed. "Occlusion will be maintained for a total of 1 hour and the balloons will be deflated and removed."

"The animal will then be euthanized ... necropsied ... for histological analysis."

If the PI was able to demonstrate that the baboon had a stoke with this procedure a grant will be received and more baboons will be ordered for future killings.

Lately, OSU has not been providing primate disposition records so the current status of this experiment is unknown.

SIDENOTE:

The PI and another reference (below) both state the flaw in using animals for research. Of course their animal is preferred and okay to use.

Recent strides in transgenic mice technology have enabled the systematic and targeted study of isolated gene products as they pertain to tissue damage in cerebral ischemia. Unfortunately, efforts to translate many of these pathophysiological findings to the clinical realm have failed, in part because of a growing realization of significant species-specific differences in responses to ischemic injury. (Stroke. 2000 Dec;31(12):3054-63)

The PI submits in the protocol, "Stroke therapy development has been plagued by failures in human clinical trials despite robust neuroprotection observed in rodent models."

Yet Courtney DeVries (another animal researcher at OSU) is currently using thousands of mice to "examine the effects of prior exposure to positive social interaction versus social stress on the consequences of experimental stroke." This is an E protocol where the mice are stressed and experimentally suffer a stroke. You can read more at Sociobiological Factors in Experimental Stroke Outcome.

The statements above seem to indicate that these experiments should stop today and efforts be refocused to directly help and support humans suffering from stroke injuries.