2006A0248 - Treatment of Canine Focal Cerebral Ischemia with Natural Vitamin E - Chandan K. Sen - Pain Code 4D
Approval to use 75 dogs to "evaluate the potential of vitamin E and its analogs to protect against stroke damageon the basis of the anti-oxidant activity of these agents" in the dog's brain.
The aims of the study include the following:
A grant has been received from the National Institute of Neurological Disorders and Stroke and will run from January 2008 to December 2011. An intereting omission from the CRISP report (online resource) is that "there are no thesaurus terms on file for this project", so anyone investigating protocols using dogs would not know that dogs are used in this experiment.
From December 2007 to March 13, 2008 atleast 25 dogs were killed in this experiment. All dogs came from Robert Perry.
We have requested an explaination (3/31/08) about the approved protocol procedures, because it appears the protocol is not being followed as written.
Studies vary as to the effectiveness of Vitamin E and stroke prevention. Our view is that human studies are enough to address this issue. A vegetarian diet helps in that area as good sources of vitamin E include sunflower and safflower oils, oil-based salad dressings, almonds, sunflower seeds, peanut butter, and dark leafy greens.
Here are some sources which discuss a variety of human trials. We say stop using all animals for these investigations.
Vitamin E and beta carotene supplementation in high risk for stroke: a subgroup analysis of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.Leppälä JM, Virtamo J, Fogelholm R, Albanes D, Taylor PR, Heinonen OP.
Vitamins: Nutrition Source, Harvard School of Public Health - A general article discussing taking multivitamins
Vitamin E and its Role
in the Prevention of Atherosclerosis and Carcinogenesis: A Review
Anand Dutta, BSc and Sudhir K. Dutta, MD