Dogs at Ohio State University


Ohio State University uses a variety of sources to keep the supply of dogs used by experimenters and instructors flowing into the university. The numbers of dogs used is dependant upon open research projects.

2001
Dogs Used = 485
2002
 Dogs Used = 524
2003
 Dogs Used= 418
2004
Dogs Used = 315
2005
Dogs Used = 264
2006
 Dogs Used = 310
2007
 Dogs Used = 272

USDA Class A dealers sell purpose-bred dogs. Marshall Farms in New York is one facility where OSU buys dogs.

Robert Perry, Mt. Sterling, is a USDA Class B dealer, who primarily buys dogs from individuals around Ohio, Kentucky, and West Virginia as well as breeds dogs.

Seth Perry, son of Robert Perry, had this commentary published in the Chronicle of Higher Education.LIVES IN THE BALANCE
The ethical quandaries of using animals in research are a little less abstract when providing those animals is the family business, writes Seth Perry, a Ph.D. student in the history of Christianity at the University of Chicago Divinity School.

We have been asked to remove the article from our website by the Chronicle with this comment, "As a subscription-based publication, we do not permit Chronicle-owned material to be electronically reproduced, distributed, or posted on other web sites." http://chronicle.com/weekly/v53/i21/21b01401.htm

Our response to the article is Not Really

Dogs obtained from Robert Perry are used in atleast eleven (11) protocols and the number of dogs used could reach eight hundred thirty (830).

Other facilities providing dogs to OSU include:

Springborn Labs, a subsidy of Charles River located in Spencerville, Ohio. After our 2003 protest at Springborn the company removed their website from public view.

WIL Research Laboratories, located in Ashland, Ohio has been delivering beagles to OSU for a number of years.

Battelle Memorial Institute, Columbus, provides beagles for a variety of experiments at OSU.

Some research projects are funded by the Ohio Canine Research Fund. The monies come from every county in Ohio via the sale of dog licenses. Ten cents (.10) of every dog license sold in the state goes to this fund.

Protocol titles highlighted have received dogs. At this time POET is receiving Animal Disposition records after the dogs are killed not when they arrive at OSU as in previous years.

Approved Protocols Using Dogs

Protocol
Title
Principal Investigator
Number of Dogs-Status
2007A0106
 Short Course in Bioinstrumentation Robert Hamlin
 12 dogs for instructional protocol to observe instrumentation and recording of the heart - dogs are killed at the completion of the class - mice, rats, and rabbits are also used.
2007A0091
 Heart Failure and Atrial Fibrillation Cynthia Carnes
 119 dogs to determine how heart failure causes atrial fibrillation.
2007A0090
 Comparison of Fluids and No Fluid Administration for Treatment of Isoflurane-Induced Hupotension Richard Bednarski
 8 dogs to determine how quickly blodd pressure returns to normal after administration of two types of fluids, and how long maintained. Effects on blood chemistry and the cardiovascular system.
2007A0086
 Evaluation of Potential Predictors for Respiratory Disease in Dogs in an Animal Shelter Linda Lord
 120 dogs to ascertain if any of several biological parameters can be used to predict which dogs housed in an animal shelter environment will develop respiratory disease.

2007A0081
2004A0093

 Cardiovascular Effects of Omega-3 Fatty Acids George Billman
 120 dogs
40 dogs had been approved for the 2004 protocol.
2007A0050
 Analysis of Bone Adaptation Supporting Miniscrews Sarandeep Huja
 6 dogs to test two screw types to aid in the development of nondestructive methods to evaluate the clinical & biological basis of adaptation in bone around miniscrews.
Dentistry
2007A0041
 Effect of Treatment with Low Doses of Hydrocortisone on Blood Pressure and Mortality in Dogs with Septic Shock Shane W. Bateman
 10 owner dogs that are already hospitalized in the ICU at the OSU Veterinary Hospital. Animal use is limited to blood sampling and administration of hydrocortisone or placebo treatment.

2007A0038
2001A0046
1995A0019

 Continuing Education: Total Hip Replacement Jonathan Dyce

30 dogs used for veterinary surgeons to teach the principles of hip replacement and perform total hip replacement in dogs.

Dogs received from Robert Perry
2007A0037
 Exploring the Mechanisms of Postoperative Ileus in a Canine Model Fedias Christofi
 105 dogs used to develop a therapeutic treatment for Postoperative Ileus (POI), a condition of gastrointestianl impairment following abdominal surgery.

2007A0032

2004A0025

 Effect of Oxyglobin on Pulmonary Hemodynamics & Hypoxic Vasoconstriction in Dogs William W. Muir
 6 dogs will be used to evaluate the effects of Oxyglobin, a drug used for carrying oxygen to organs and tissues of the body, on the ability of dog lungs to function correctly.
2007A0012
 Cardiac Medical Device Efficacy Valerie Bergdall

90 pigs and /or 90 dogs feasibility of using a less invasive approach to correct a leaky valve (from heart valve replacement surgery).
A pilot study will decide which species to use - children's

Dog received from Perry March 2007 - killed.

2006A0263

2003A0193

 Medical Training Wet Labs Valerie K Bergdall
 260 dogs - this is a Wet Lab - a variety of other animals are used as well inclkuding cats.
2006A0258
 Biphosphonate Associated Osteonecrosis Following Extraction & Implant Placement Sarandeep S. Huja
 4 dogs, 10 mice for remodeling of the jaw od adult dogs after using intravenous biphosphonates.
2006A0248
 Treatment of Canine Focal Cerebral Ischemia with Natural Vitamin E Chandan K Sen

75 dogs evaluate vitamin E for protection against stroke

Dogs received from Robert Perry last killed May 2007.

2006A0235

2003A0177

 The Cardiorespiratory Safety of an Injectable Anesthetic Following Premedication William W Muir

46 dogs to test an injectable anesthetic used for dogs.

Dogs received from Battelle.
Dogs received from Covance killed Feb. 2004.
2006A0215
 Role of Bioglue in Robotic Assisted Laparoscopic Prostatectomy Vipul R Patel
15 dogs testing to reduce urinary leakage and to remove the cartheter earlier from these surgeries.

2006A0205
2003A0160

Mechanisms of Cardiac Resynchronization Therpy Cynthia A Carnes

36 dogs to understand the mechanisms by which bi-ventricular pacemakers work in heart failure and to ultimately use this information to determine which patients should receive this type of pacemaker.


pain coder modified after procedures chged from 4D to 5D

40 dogs approved in 2003.

2006A0204
 The Effect of Two Doses of a Novel Anti-Inflammatory Analgesis on Pain and Imflammation in Dogs William W Muir
 14 dogs xfr 2005A0034
Dogs are the target species to help determine rational dosage regimens
2006A0183
 MRI MOnitoring Convection Enhanced Delivery in the Brain Michael V Knopp
 7 dogs from 02A0108 to explore alternative techniques for delivery of chemotherapy and other treatments for brain disorders including tumors.
2006A0173
 Myocyte Calcium Regulation in Heart Failure Cynthia A Carnes
 100 dogs to investigate how adnormalities in internal calcium regulation causes impaired contraction of cardiac muscle cells.
2006A0169
 Clinical Efficacy of Topical Aldose Reductase Inhibitor (Kinostat) for Prevention of Sugar Cataract Carmen M Colitz
 30 client-owned dogs testing efficacy of kinostat
2006A0160 2003A0122
 Surgical Device Evaluation: Acute Studies Benjamin Sun
 70 dogs other animals used to develop, test, and validate new cardiac surgical devices.
2006A0147
 Effects of Neural Stimulation Therapy on Dogs with Chronic Heart Failure Robert L Hamlin
 12 dogs to test the efficacy of an implant device used to stimulate the vagosympathetic trunk.
2006A0126
 Aortic Blood Flow by NMR & Echo Robert L Hamlin 16 client-owned and
8 purchased dogs
2006A0112
 Novel Repair Techniques of GAstro-Intestinal Perforations William S Melvin
 35 dogs - a pilot study for laparoscopic interventions -
Dogs from Robert Perry last killed Sept. 2006.
2006A0109
 Laparoscopy Surgery Walter R Threlfall
 120 dogs, 120 cats - instrutional using cadaver animals .
Veterinary Clinical Sciences
2006A0108 Canine Theriogenology Walter R Threlfall

12 owner dogs - instrutional course with dogs returned to owner

Veterinary Clinical Sciences
2006A0107 Veterinary Laser Surgery Continuing Education Course Walter R Threlfall
 72 dogs, 72 cats, 36 chickens and 36 rabbits providing hands-on training in a laser surgery techniques
Veterinary Clinical Sciences
2006A0106 Estimation of Central Venous Pressure by Ultrasound of the Quadrate Hepatic Vein in Dogs William T Drost
 10 dogs
Veterinary Clinical Sciences
2006A0099
 Basic and Advanced Veterinary Ultrasound Walter R Threlfall 60 client-owned dogs
60 client-owned cats
instructional ultrasound - dogs returned to owners
Veterinary Clinical Sciences
2006A0052
 Anti-Arrhythmic Drug Testing George Billman
 120 Dogs used to test whether or not drugs that regulate the movement of potassium or calcium across the cell membrane of heart cells can prevent sudden cardiac death.

2006A0051
2000A0053 - 1993A0246

Mechanisms Responsible for Ventricular Fibrillation George Billman

90 dogs with 14 added 6/27/06
The dogs are used to investigate the effects of exercise on the nerves that control heart rate.

Protocol 2000 approved 150 dogs with another 48 dogs added in March 2005.

120 dogs were approved for use in 93A0246

2006A0023

2003A0023

 Cardiovascular & Respiratory Effects of a new Intravenous Anesthetic in Dogs William W Muir

6 dogs to evaluate new intravenous anesthetic in dogs.

From 2003 - 16 dogs approved - 8 dogs received from Marshall Farms in May (4) & July (4).

2 cats were added as a pilot to study effectiveness in this species.

3/05 6 dogs were added for FDA Vet Medicine drug safety testing.

2006A0021
2003A0014
1996A0111

 Pharmacology Course 793 William W Muir
 6 dogs to demonstrate differences in heart rate and other vital measurements seen when pharmacological drugs are given.
P.O.E.T. believes alternatives to this course are available. Letter to OSU March 8, 2003 - No response
2005A0208 Gene Therapy for Duchennes Muscular Dystrophy Jerry R Mendell
 4 dogs initially with 30 dogs added in July 2006.
Dogs from Battelle last killed July 2006/
2005A0207 Pilot Study for Evalaution of Novel Anti-Inflammatories William W. Muir
 4 dogs to establish a model for pain assessment in dogs.
2 dogs added June 2006
2005A0206
 Left Ventricular Dysfunction Quantified by Mycardial Strain Imaging in Canine Mitral Valve Disease John D Bongura

8 dogs given cardiac catherization and will attempt to adopt or transfer the animals

Dogs from this protocol have been transferred to other protocols-2006A0106 & 2005A0072

Funded by the Canine Research Fund
2005A0192
 Inhalation Sparing Effects of a Novel N-Methyl-D-Aspartate Antagonist William W Muir 8 dogs for testing of drugs
2005A0191
 Evaluation of Hyperviscous Fluid Resusitation in a Canine Del of Hemorrhagic Shock William W Muir 15 dogs with 8 dogs added in April 2006. A percentage are added in the event of experimental failure.
funded by the Ohio Canine Research Fund
2005A0188
 Synthetic MicroRNA Therapy for Relapsed Canine Lymphoma Laura Rush
 3 owner dogs to study the drug - dogs are already in ICU at OSU Veterinary Hospital.
2005A0164
 Amiodarone and CSF (cerebrospinal fluid) Pressure Deborah Grzybowski
 10 dogs transferred from other protocols and adding 32 dogs in Feb 2006 to understand why amiodarone, a drug to control heart rhythm, has been reported to cause sudden, brief increases in CSF pressure.
2005A0132 Drug Effects in Heart Failure Robert Hamlin 120 dogs
2005A0131
 Role of Carvedilol for Prevention and/or Treatment of Doxorubicin-Induced in Dogs Robert Hamlin 18 dogs to see if carvedilol will help prevent or minimize heart failure produced by using Doxorubicin.
2005A0116
 Cardiovascular Effects of Escalating Doses of Bisoprolol Robert Hamlin
 4 dogs with dogs released to other protocols.

2005A0103
99A0120

93A0161

Development of New Diagnostic Method & Vaccine Against Ehrlichiosis Yasuko Rikihisa

50 dogs - some dogs from Robert Perry - last killed Sept. 2006.

from 1999 - 64 dogs approved - funded by Canine Research Fund (.10 of every dog license sold in the state goes to this fund)D ogs received from Marshall Farms Feb. 2003.
2005A0096 Slug Expression during Normal Corneal Wound Healing in Dogs Donna F Kusewitt 12 dogs
2005A0095 Introcular Toxicity of Compounds Inhibiting Posterior Capsule Opacification Carmen M.H. Colitz 30 dogs to review cataract surgery procedures.While the PI stated that dogs will come from other protocols 16 dogs were received from Batelle (8/26/05) and killed 8/26/05. Aa amendment to the protocol was submitted 8/29/05 to modify the procedures.
2005A0079 Negative Inotropic Effects of Antiarrhythmic Drugs Robert L Hamlin

8 dogs after use will transfer to other protocols

5 additional dogs transferred from 2005A0132 approved July 2006

2005A0072 Regulation of Intracellular Calcium in Cardiac Myocytes Cynthia Carnes

42 dogs to understand how calcium is regulated in the heart.

Dogs received from Battelle, Perry and from protocol transfers - funded NIH

2005A0065
99A0039

 Cir Tech 450 Cardiopulmonary Monitoring and Assessment Richard Tallman 12 dogs
2005A0061 Functional Effect of Inotropic Agents in Myocytes Isolated from Canines Kathryn M Meurs 30 dogs - inotropic drugs are given to the dog and then the heart is removed and used for further experimentation.
2005A0039 Evaluation of Cryoablation Devices for the Treatment of Atrial Fibrillation John Sirak

35 dogs testing modifucations of FDA device currently used in human medicine.

Nine dogs were received from Perry in April 05. Eight have already been killed in this project.
2005A0034 The Anesthetic Effects of Propofol in Premedicated Dogs William W Muir

46 dogs used for safety test

Dogs were received from Marshall Farms.
2005A0020 Cardiac Effects of Methadone Robert Hamlin 20 dogs all killed at the end of the study
2004A0196 Noninvasive Prediction of Congested Heart Failure in Dogs by Doppler Echo Karsten Schober

7 dogs received from Robert Perry last killed June 2006.

Funded by the Canine Research Fund
2004A0168 Effect of Pacing Sites & Intervals of Biventricular Synchrony Robert Hamlin 24 dogs from Perry & Battelle to address the usefulness of resynchronization therapy and what degree of synchrony may be required.

2004A0143
98A0079

92A0142

CT 513 - Applied Circulation Technology - In Vivo Lab Richard Tallman

66 dogs - Dogs from Perry last killed Nov. 2006.

from 1998 - 78 dogs approved - Dogs used are received from Robert Perry.
2004A0094
98A0060		 Tick Transmission of Ehrlichia Roger W. Stich

888 dogs since 2001. Some dogs are transferred to other protocols.

Dogs received from WIL Labs.

from 1998 - 518 dogs approved

2004A0063 Local Delivery of Drugs to the Bladder Valerie Bergdall

60 (beagle) dogs were approved and were received from WIL Laboratories in Oct 2005. The dogs were transferred to 2002A0108.

An amendment submitted in Dec. 2005 stated mice would now be used.

2004A0059 Affect repeated anesthesia with morphine-chloralose on barorector sensitivity in normal dogs Robert Hamlin

12 dogs to determine the safety of the anesthetis.

Dogs appear to be donor dogs to OSU last killed May 2006.

2004A0058 Studies on baroreceptor sensitivity in normal dogs Robert Hamlin

24 dogs to investigate baroreceptor response in dogs given sildenafil or vardenafil - drugs used for erectile dysfunction.

Dogs received from Battelle with last killed Sept. 2006.

2004A0038 A Canine Model for Targeted Gene Delivery to the Pancreas Peter Muscarella

10 dogs to evaluate techniques for gene therapy administration.

Dogs from Robert Perry
2003A0153

Omega-3 Free Fatty Acids & Atrial Electrophysiologic Remodeling

 Cynthia M Carnes

24 dogs to test whether omega-3 will reduce the likelihood of developing atrial fibrillation.

11/04 4 dogs requested to replace 4 dogs who developed atrial fibrillation spontaneously.

6 additional dogs were approved Sept 2005 asthe PI had a "question from reviewers about the pharmacokentics of the omega-3 free fatty acid."

There is a note on one of the animal disposition records from 9/7/05 - "If the dog cannot be here tomorrow the PI does not want it!"

Dogs have been received from Robert Perry last killed Sept 2005.

2003A0117 Oxidant Production In Atrial Fibrillation Cynthia Carnes

30 dogs to test the usefulness of Vitamin C as a non-toxic therapy for atrial fibrillation.

Dogs were received from WIL Laboratories last killed Nov. 2005.
2003A0044 ULAR Animal Holding Protocol William Yonushonis a large variety of animals held for future protocols - Some dogs from WIL Labs.
03A0046 Gene Expression Profiling of Relapsed Lymphoma in Dogs William C. Kisseberth 50 client animals - no euthanasia unless requested by owner
03A0031 Energetics in IBMX in Dogs Robert Hamlin 24 dogs approved - 20 dogs from Marshall Farms received 4/23/03 and all have been killed.
02A0168 Oral Glucosamine Therapy of Canine Osteoarthritis Kenneth A Johnson 105 client-owned dogs returned to owners
02A0166 Test of Bronchodilators in the Dog Robert Hamlin 48 dogs approved - 26 dogs killed from Springborn, Battelle, and Perry
02A0165 Application of Positive/Negative Pressure Ventilation in CPR/Shock Robert Hamlin 24 dogs & 24 pigs approved for use - April 05 an additional 24 pigs were approved for use.
02A0147 - 96A0142 Suramin Distribution to Selective Organs in Dogs After Systemic Administration M. Guill Wientjes 188 dogs approved - dogs used are from Battelle, WIL, and Springborn
02A0119 Development of a TSH Stimulation Protocol in Normal Dogs Philip A March 10 dogs approved - funding via Canine Research Fund - dogs expected to be transferred to other protocols or killed if unresponsive to treatment.
Develop safe and reliable thyroid stimulating hormone (TSH) stimulation test.
02A0112 Effects of an Analgesic Infusion on Minimum Alveolar Concentration in Dogs William Muir 18 dogs approved - Dogs received from Perry
02A0108 Measurement of Prostate Volume in Dogs

Thomas J Rosol

new PI 9/03 Michael V Knopp

45 dogs approved - 30 dogs received from Marshall Farms Dec. 12, 2002. All killed between April 14-15, 2003. 15 dogs received from Robert Perry.

Dogs also received from Battelle.
Dogs transferred from 2004A0063 (WIL Lab dogs) all killed Nov. 2005.
Testing efficacy or usefulness of a new drug

02A0107 Measurement of Post-ischemic Injury in the Heart Jay Zweier Originally using hundreds of rats & mice the protocol has expanded over the years to now include100 rabbits and 13 dogs (june 2006) with 3 dogs received from Robert Perry in April/May 2007 and all killed.
02A0099 Isoflurane sparing in dogs by acupuncture, electroacupuncture, and transcutaneous cranial electrical stimulation Roman T Skarda 10 dogs approved - transferred from 15 dogs received from Perry & Battelle - lasted killed in Feb/March 2003
02A0096 Mechanisms of Atrial Remodeling Cynthia A Carnes 108 dogs approved - 15 dogs received from Perry & Battelle - lasted killed in Feb/March 2003
Funded by American Heart Association
02A0095 Modulation of Atrial Function by Glutathione Depletion Cynthia A Carnes 50 dogs approved - 39 dogs received from Battelle, WIL, Springborn, & Marshall Farms - lasted killed July 2003.
02A0090 Bone Development Around A Tooth Sarandeep Huja 12 dogs to examine the effects of dynamic forces on bone in the head (tooth development) Dogs were received from Ridglan Farms.
02A0082 Anesthetic-Sparing Effects & Anesthetic Recovery Effects of an NK1 Antagonist in Dogs William Muir 8 dogs approved
Determine effects and safety of test article
02A0081 Evaluation of the Allergens of the Storage Mite Tyrophagus Putrescentiae in Dogs Andrew Hiller 3 dogs approved will transfer to other protocols
Dogs received from Inhauser Research Institute, Ft. Collins, CO.
02A0079 QTc Prolongation of a Test Article in Dogs with Heart Failure Robert Hamlin 8 dogs approved - 3rd year review (4/05) added 64 dogs to this experiment.
02A0066 Comparison of Anesthetic Inhalants in Dogs William Muir 8 dogs approved - All dogs received from Perry and killed. Study complete
02A0065 Assessment of the Normal Canine Left Ventricular Outflow Tract Kathryn M Meurs 7 dogs approved - dogs used are from protocol 02A0009. After assessment will go back to the study.
02A0039 Ultracision Study Randall K Wolf 12 dogs approved
Test of new surgical device used during graft in coronary artery bypass surgery.
02A0037 Evaluation of the Alpha-Stat & the ph-Stat Approaches for the Treatment of Hemorrhagic Shock & Vascular Hypoeactivity in Dogs William Muir 42 dogs approved - Dogs received from Perry and Battelle.
02A0023 Does Interleukin 6 Play a Role in Glucose Homeostasis in Exercising Dogs Kenneth W. Hinchcliff 8 dogs approved - Animals will be adopted if suitable as pets. Otherwise transferred or killed.
02A0013 Distal Anastomotic Device Project Randall K Wolf 90 dogs approved
02A0009 Antiarrhythmic Effects of a Novel Amiodarone Robert Hamlin 48 dogs approved
01A0148 Mechanisms Responsible for Myocardial Stunning George Billman 40 dogs approved - does not appear any animals received (see 02A0102 using 90 rats)
01A0143 Effects of Anesthesia on Urodynamic Measures in Normal Dogs Philip A March 12 dogs approved from Battelle & transferred to Skarda, 02A0099, and then some adopted.
01A0122 Canine Hepatic Vein Evaluation Using Doppler Ultrasound James S Mattoon

12 dogs approved - 6 dogs received from Robert Perry in 2002. Dogs to be transferred to other protocols or adopt.
01A0113 Anchors to Move Teeth Sarandeep Huja 8 dogs approved & received from Battelle.
Testing how easy or difficult it is to pull out a special screw after it has been inserted into the jaw bone.
01A0105 In Vivo Use of Bioactive Glass as a Carrier for Therapeutic Agents for Grafting of the Paranasal Sinuses John Mitchell 10 dogs approved
01A0104 Advanced Surgical Techniques & Device Training Randall Wolf 420 dogs approved - No dogs received to date in 2003. Training for surgery using the daVinci Surgical System, a computer-guided robotic surgery assist. Note: 432 pigs and 36 weanling cattle were also approved for use
01A0097 The Chemical Basis of Ischemic Injury-Development of an Appropriate Model Hamdy Awad 35 dogs approved - Dogs from Marshall Farms - last killed April 2003.
Establish a dog model of ischemic spinal cord injury.
01A0095 Evaluation of Angiogenesis Inhibitor NM-3 on Canine Purkinje Fibers S Mark Strauch 24 dogs approved - Dogs from Springborn & Covance. Study seems complete - no new amenments or animals since 2001.
01A0086 In Vivo Use of Bioactive Glass as a Carrier for Therapeutic Agents John Mitchell 9 dogs approved
Understanding effect of new material on tooth and bone loss.
01A0069 Hyperhomocysteinemia and Cardiac Function Cynthia Carnes 64 dogs approved
01A0037 - 95A0031 Local Delivery of Drugs to the Bladder or Prostate of Dogs M Guill Wientjes 246 dogs approved - Lasted dogs received from Battelle August 1 & 21, 2003. Some already killed August 12, 2003.
01A0028 Serum TroponinI & Electrocerdiogram of Alaskan Sled Dogs Kenneth W Hinchcliff 800 sled dogs approved - Data collected during the Iditarod Trail Sled dog race.
01A0017 Management of Wobbler Syndrome in Large-Breed Dogs with a Modified Distraction-Stabilization Techniques Using a Cervical Interbody Fusion Device Jonathan Dryce 20 client-owned dogs returned to owners
99A0145 620 Vet Med Robert Sherding 144 dogs approved - Dogs are received from Perry and killed with 2-3 days of arrival.
98A0084 Interventions to Promote Ventilator Weaning Kathleen Stone

116 dogs approved - Dogs are received from Robert Perry on a regular bases. Generally killed within 1-2 days. Lasted dogs arrived August 11, 2003.

Retired or left the university.

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Updated July 12, 2007