Rabbits Used at OSU

2007A0033 - Development of Synthetic Peptide Vaccines - Parvin T.P. Kaumaya - 150 Rabbits (600 mice)

These experiments began in 1998 (Protocol 98A0021/2004A0044) with the approval to use mice and rabbits. Rabbits are used for polyclonal antibody production.
2004A0044 - 300 rabbits & 3,750 mice
98A0021 - 360 rabbits & 4,500 mice

2007A0025 - Studies for the Development of Antifertility Vaccines - Vernon C. Stevens - 340 Rabbits
These experiments actually began in 1992 and have used rabbits for antibody production and immunogenicity.
2004A0033 - Vernon C Stevens - 600 rabbits
98A0034 - 300 rabbits
92A0119 - 800 rabbits

2006A0259 - Role of Oxygen in Dermal Wound Healing - Chandan K Sen - 80 NZ Rabbits

These experiments began in 2000 (Protocol 2000A0173 )with the approval to use mice. Rabbits were added in the 2006 protocol and will be used extend the study investigating "the dynamics of oxygen concerntration in dermal wound healing in larger animals and also to determine the toxicity, if any, of the probes to be used."

The implants are OxyChips that "enable us to measure the oxygenation as well as the oxygen comsumption at the wound site and the oxygen gradient formes."

2006A0207 - Exercise Driven Molecular Mechanisms of Osteoarthritis - Sudha Agarwan - 87 Rabbits

These experiments began in 2003 (Protocol 2003A0138) with the approval to use 120 rabbits. An additional 60 rabbits were approved for use June 2004.

2006A0131 - Influence of Troponin C on the Rate of Cardiac Relaxation - Svetlana B. Tikunova - 150 NZ Rabbits

The rabbits are used as a means to collect heart muscle tissue (cardiac trabecules). 150 rats were also approved for use.

2006A0129 - Molecular Mechanisms of HTLV Infection and Disease - Michael D. Lairmore - 87 Rabbits

These experiments began in 2000 (Protocol 2000A0074) with the approval to use 120 rabbits. The aims are "refine a rabbit model to test the molecular determinants of regulatory genesof the virus that influence how the virus spreads in the body. ... We will compare the effects of each mutation in virus replication" using the rabbit model. Rabbits do not develop the disease and are used an infection model. 320 mice have also been approved for use over the length of the protocol.

2006A0084 - Structural and Conformational Aspects in Peptide Vaccines (HTLV-1) - Pravin TP Kaumaya - 318 NZ Rabbits

These experiments began in 2003 (Protocol 2003A0026) with the approval to use 36 squirrel monkeys. 16 Squirrel monkeys were received from the Buckshire Corporation on October 22, 2003. All the primates received the first vaccinations on 12/22/03 and lived until a "terminal blood draw" was taken on 10/26/05, at which time all 16 primates were killed.

The 2006 protocol did not request primates but requested the use of 319 rabbits and 940 mice. The rabbits will provide "a well established infection model to test the ability of fusion inhibitor therapeutics to reduce HTLV-1 proviral load in vivo."

2006A0038 - Biological Effects of Peptides/Antipeptide Antibodies in Her-2/neu and VEGF - Pravin TP Kaumaya - 50 NZ Rabbits

These experiments began in 1997 (Protocol 97A0020) with the approval to use mice and rabbits. Rabbits are used for polyclonal antibody production.

2005A0204 - Adaptation of Skeletal Muscle to Repetitive Strain Injury - Thomas M Best - 26 NZ Rabbits - additional 12 rabbits were approved for use 11/27/06

2005A0154 - Polyclonal Antibody Production - Richard A Fishel - 252 Rabbits

2005A0150 - Low Load Behavior of Skeletal Muscle: An Improved Understanding of Injury and Healing - Thomas M Best - 50 NZ Rabbits

Rabbits are given a "stretch injury" to the right Tibialis Anterior tendon with the left serving as control. The injury is created by shortening the tendon.

2005A0139 - Degradation and Biocompatibility of a Magnesium Bone Void Filler in Rabbits - Alicia L Bertone - 47 NZ Rabbits

These experiments will evaluate a new "magnesium based paste that is initially a liquid and therefore can be injected." Rabbits are given a bone void via drilling a hole in the femur. The void is then filled with the bone filler. The rabbits are killed at 16 and 52 weeks.

2005A0135 - Human Hematopoietic Growth Factors - Belinda R Avalos - 18 Rabbits

These experiments began in 1993 (Protocol 93A0116/99A0091) and the rabbits are used for anitibody production.

2005A0119 -Neuronal Plasticity in the Retina - Stuart Mangel - 840 Rabbits

2005A0118 - Chloride Cotransporter Function in the Rabbit - Stuart Mangel - 500 Rabbits

2005A0110 - Free Radical Production Following Postconditioning in Rabbits Hearts - Mark Angelos - 36 NZ Rabbits

2004A0192 - Robert L Hamlin - 120 Rabbits

2004A0180 - Arturo J Cardounel - 144 Rabbits - additional 25 2/25/05

2004A0138 - Terry S. Elton - 2 Rabbits

2004A0118 - Alicia Bertone - 60 NZ Rabbits

Updated: Feb. 25, 2007